Mitiglinide Calcium (KAD-1229)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $645 | Check With Us |
| 10g | $950 | Check With Us |
| 20g | $1425 | Check With Us |
: Cat #: V1679 CAS #: 145525-41-3 Purity ≥ 98%
Description: Mitiglinide Calcium (formerly KAD-1229; S-21403; KAD1229; S21403; Glufast), the calcium salt of Mitiglinide, is a potassiun channel blocker that has been approved as a blood glucose-lowering drug for the treatment of type 2 diabetes.
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| Molecular Weight (MW) | 668.88 |
|---|---|
| Molecular Formula | (C19H24NO3)2.Ca |
| CAS No. | 145525-41-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: <1 mg/mLr |
| Water:<1 mg/mLr | |
| Ethanol: 2 mg/mL (2.99 mM) | |
| SMILES Code | O=C([O-])C(CC1=CC=CC=C1)CC(N2C[C@]3([H])CCCC[C@]3([H])C2)=O.O=C([O-])C(CC4=CC=CC=C4) CC(N5C[C@]6([H])CCCC[C@]6([H])C5)=O.[Ca+2] |
| Synonyms | KAD-1229; S 21403; KAD 1229; S21403; KAD1229; S-21403; Mitiglinide calcium; Glufast. |
| Protocol | In Vitro | Mitiglinide Calcium inhibits the Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50 value, 100 nM) but does not significantly inhibit either Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (more than 10 μM) in COS-1 cells |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.4950 mL | 7.4752 mL | 14.9504 mL | 29.9007 mL |
| 5mM | 0.2990 mL | 1.4950 mL | 2.9901 mL | 5.9801 mL |
| 10mM | 0.1495 mL | 0.7475 mL | 1.4950 mL | 2.9901 mL |
| 20mM | 0.0748 mL | 0.3738 mL | 0.7475 mL | 1.4950 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.