Mildronate | CAS 76144-81-5

Mildronate

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
1g	$390	Check With Us
2g	$590	Check With Us
5g	$995	Check With Us

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Cat #: V0934 CAS #: 76144-81-5 Purity ≥ 98%

Description: Mildronate (Quaterin; Meldonium; Kvaterin; Mildronate), a structural analogue of gammabutyrobetaine and performance-enhancing drug developed by Latvia Institute of Organic Synthesis, is a potent inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase, also a competitive inhibitor of renal carnitine reabsorption.

References: Dambrova M, et al. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacol Res. 2016 Nov;113(Pt B):771-780.

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Physicochemical and Storage Information
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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	147.19
Molecular Formula	C6H14N2O2
CAS No.	76144-81-5
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 29 mg/mL (197.0 mM)r
	Water: <1 mg/mLr
	Ethanol: 29 mg/mL (197.0 mM)
SMILES Code	O=C([O-])CCN[N+](C)(C)C
Synonyms	Quaterin; Meldonium; Kvaterin; Mildronate;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	6.7939 mL	33.9697 mL	67.9394 mL	135.8788 mL
5mM	1.3588 mL	6.7939 mL	13.5879 mL	27.1758 mL
10mM	0.6794 mL	3.3970 mL	6.7939 mL	13.5879 mL
20mM	0.3397 mL	1.6985 mL	3.3970 mL	6.7939 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.