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| Size | Price | Stock |
|---|---|---|
| 10g | $100 | Check With Us |
| 50g | $250 | Check With Us |
| 100g | $375 | Check With Us |
: Cat #: V1480 CAS #: 443-48-1 Purity ≥ 98%
Description: Metronidazole (trade names Flagyl, Metro, Trichopol, Vagilen), an imidazole-based and synthetic antibacterial and antiprotozoal drug belonging to the nitroimidazole class, is commonly used for the treatment of protozoa and other baterial infections.
References: Scully BE. Metronidazole. Med Clin North Am. 1988 May;72(3):613-21.
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- Related Biological Data
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| Molecular Weight (MW) | 171.15 |
|---|---|
| Molecular Formula | C6H9N3O3 |
| CAS No. | 443-48-1 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 34 mg/mL (198.7 mM)rr |
| Water: <1 mg/mLrr | |
| Ethanol: <1 mg/mL | |
| Synonyms | Flagyl, Metro, Trichopol, Vagilen |
| Protocol | In Vitro | In vitro activity: Metronidazole is relatively inactive until it is metabolized within host or microbial cells. Metronidazole is activated when it receives an electron from ferredoxin or fla vodoxin that is reduced by POR in anaerobic or microaerophilic bacteria or luminal parasites. Metronidazole damages cells by forming protein and DNA adducts. Metronidazole has activity against protozoans like Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis, for which the drug is first approved as an effective treatment. The activity of metronidazole against anaerobic bowel flora has been used for prophylaxis and treatment of patients with Crohn's disease who might develop an infectious complication. Metronidazole has played an important role in anaerobic-related infections. Metronidazole has notable effectiveness in treating anaerobic brain abscesses. Metronidazole resistance tends to result from de novo mutation in the resident rdxA gene, rather than from lateral transfer of mutant rdxA (or other) genes from unrelated but Mtzr strains. Metronidazole partially inhibits growth stimulate forward mutation to rifampin resistance in rdxA(+) (Metronidazole(s)) and also in rdxA (Metronidazole(r)) H. pylori strains, and that expression of rdxA in Escherichia coli results in equivalent Mtz-induced mutation. Metronidazole leads to apoptosis-like features in growing cultures of axenic B. hominis, including key morphological and biochemical features of programmed cell death (PCD), viz. nuclear condensation and nicked DNA in nucleus, reduced cytoplasmic volume, externalization of phosphatidylserine and maintenance of plasma membrane integrity with increasing permeability. |
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| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 5.8428 mL | 29.2141 mL | 58.4283 mL | 116.8566 mL |
| 5mM | 1.1686 mL | 5.8428 mL | 11.6857 mL | 23.3713 mL |
| 10mM | 0.5843 mL | 2.9214 mL | 5.8428 mL | 11.6857 mL |
| 20mM | 0.2921 mL | 1.4607 mL | 2.9214 mL | 5.8428 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.