Mesoridazine free base
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $450 | Check With Us |
| 250mg | $650 | Check With Us |
| 500mg | $975 | Check With Us |
: Cat #: V25309 CAS #: 5588-33-0 Purity ≥ 99%
Description: Mesoridazine is a potent phenothiazine dopamine receptor anatagonist that is able to inhibit D2DR and D4DR.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 386.57 |
|---|---|
| Molecular Formula | C21H26N2OS2 |
| CAS No. | 5588-33-0 |
| SMILES Code | O=S(C(C=C1N2CCC3N(C)CCCC3)=CC=C1SC4=C2C=CC=C4)C |
| Synonyms | NC-123; NSC 186066; NSC-186066; NSC186066; TPS23; TPS 23; TPS-23; Thioridazine thiomethyl sulfoxide |
| Protocol | In Vitro | Mesoridazine (15 mM; 24 h) shows total absorption of 15.94 ± 4.04% and 39.24 ± 5.11% in nude mouse and pig skin, respectively |
|---|---|---|
| In Vivo | Mesoridazine (15 mM; topical administration; once or daily for 7 consecutive days) displays potent activity and a long period of analgesia at blocking cutaneous pain | |
| Animal model | Eight-week-old female nude mice | |
| Dosages | 15 mM | |
| Administration | Topical administration, once (analgesia test) or daily for 7 consecutive days (irritation test) |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5869 mL | 12.9343 mL | 25.8685 mL | 51.7371 mL |
| 5mM | 0.5174 mL | 2.5869 mL | 5.1737 mL | 10.3474 mL |
| 10mM | 0.2587 mL | 1.2934 mL | 2.5869 mL | 5.1737 mL |
| 20mM | 0.1293 mL | 0.6467 mL | 1.2934 mL | 2.5869 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.