MCU-i4

This product is for research use only, not for human use. We do not sell to patients.

MCU-i4
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$780Check With Us
500mg$1250Check With Us
1g$1875Check With Us

Cat #: V2300 CAS #: 371924-24-2 Purity ≥ 99%

Description: MCU-i4 is a negative modulator of of the MCU (mitochondrial calcium uniporter), acting by inhibiting IP3-dependent mitochondrial Ca2+-uptake and maintaining the gatekeeping role of their target.

References: Giulia Di Marco, et al. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6.

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Product Promise

Promise
Molecular Weight (MW)377.48
Molecular FormulaC23H27N3O2
CAS No.371924-24-2
SMILES CodeO=C(C1=C(NC2=CC=C(N(CC)CC)C=C2)C3=CC(C)=CC=C3N=C1)OCC
SynonymsMCU-i4; MCUi4; MCU i4;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.6491 mL13.2457 mL26.4915 mL52.9829 mL
5mM0.5298 mL2.6491 mL5.2983 mL10.5966 mL
10mM0.2649 mL1.3246 mL2.6491 mL5.2983 mL
20mM0.1325 mL0.6623 mL1.3246 mL2.6491 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.