This product is for research use only, not for human use. We do not sell to patients.
| Size | Price | Stock |
|---|---|---|
| 100mg | $400 | Check With Us |
| 500g | $900 | Check With Us |
| 1g | $1350 | Check With Us |
: Cat #: V5177 CAS #: 159857-80-4 Purity ≥ 98%
Description: MC-Val-Cit-PAB is a novel cathepsin cleavable ADC linker that is utilized for the synthesis of antibody-drug conjugate (ADC) such as some of the FDA approved ADC drugs including brentuximab vedotin. The mechanism is like this: the Val-Cit will specifically be cleaved by catepsin B as this enzyme is only present in the lysosome, the ADC warhead/payload (the drug) will be released in the cell. The Azido group will react with DBCO, BCN or other Alkyne groups through click chemistry. The hydrophilic PEG spacer increases solubility in aqueous media.
References: [1]. Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders
Publications Citing InvivoChem Products
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 572.65 |
|---|---|
| Molecular Formula | C28H40N6O7 |
| CAS No. | 159857-80-4 |
| Storage | -20℃ for 3 years in powder formrrrrr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C(N)[C@H](CCCNC(N)=O)N(C([C@H](C(C)C)NC(CCCCCN1C(C=CC1=O)=O)=O)=O)C2=CC=C(CO)C=C2 |
| Synonyms | Mc-Val-Cit-PAB |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7463 mL | 8.7313 mL | 17.4627 mL | 34.9253 mL |
| 5mM | 0.3493 mL | 1.7463 mL | 3.4925 mL | 6.9851 mL |
| 10mM | 0.1746 mL | 0.8731 mL | 1.7463 mL | 3.4925 mL |
| 20mM | 0.0873 mL | 0.4366 mL | 0.8731 mL | 1.7463 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.