LY487379 HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $1250 | Check With Us |
| 100mg | $1850 | Check With Us |
| 200mg | $2775 | Check With Us |
: Cat #: V14550 CAS #: 353229-59-1 Purity ≥ 98%
Description: LY-487379 is a novel, potent and selective PAM (positive allosteric modulator) for the metabotropic glutamate receptor group II subtype mGluR2.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 488.91 |
|---|---|
| Molecular Formula | C21H20ClF3N2O4S |
| CAS No. | 353229-59-1 |
| Protocol | In Vivo | LY487379 hydrochloride (intraperitoneal injection; 30 mg/kg; injected 30 min before the test) requires significantly fewer trials to criterion during the ED phase of the ASST in attentional set-shifting task in male Sprague-Dawley rats. But there has no significant drug effect during any other discrimination stage |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0454 mL | 10.2268 mL | 20.4537 mL | 40.9073 mL |
| 5mM | 0.4091 mL | 2.0454 mL | 4.0907 mL | 8.1815 mL |
| 10mM | 0.2045 mL | 1.0227 mL | 2.0454 mL | 4.0907 mL |
| 20mM | 0.1023 mL | 0.5113 mL | 1.0227 mL | 2.0454 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.