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LY-3475070

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LY-3475070
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
50mg$1150In Stock
100mg$1850In Stock
200mg$2775In Stock
email: [email protected]        [email protected]

Cat #: V2260 CAS #: 2375815-63-5 Purity ≥ 98%

Description: LY-3475070 (LY3475070; LY 3475070) is a novel, potent, oral and selective CD73 inhibitor (cluster of differentiation 73, IC50 = 28 nM) with potential anticancer activity.

References: Robert Dean Dally, et al. Cd73 inhibitors. Patent WO2019168744 A1.

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Molecular Weight (MW)286.335
Molecular FormulaC15H18N4O2
CAS No.2375815-63-5
Synonyms  LY 3475070; LY-3475070; LY3475070
ProtocolIn VitroCD73-IN-3 inhibits CD73 activity in human serum with an EC50 of 0.213 μM. CD73-IN-3 inhibits CD73 activity in human serum by 56.8%, 71.7% and 76.9% at 0.52 μM, 1.56 μM, 4.68 μM,respectively
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.4924 mL17.4621 mL34.9241 mL69.8483 mL
5mM0.6985 mL3.4924 mL6.9848 mL13.9697 mL
10mM0.3492 mL1.7462 mL3.4924 mL6.9848 mL
20mM0.1746 mL0.8731 mL1.7462 mL3.4924 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Volume(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.