Lumiracoxib (CGS 35189; COX 189)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $620 | Check With Us |
| 2g | $1020 | Check With Us |
| 5g | $1600 | Check With Us |
: Cat #: V1068 CAS #: 220991-20-8 Purity ≥ 98%
Description: Lumiracoxib (formerly CGS-35189; COX-189; trade name Prexige), a non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 enzyme inhibitor with potential anti-inflammatory activity.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 293.72 |
|---|---|
| Molecular Formula | C15H13ClFNO2 |
| CAS No. | 220991-20-8 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 59 mg/mL (200.9 mM)rr |
| Water: <1 mg/mLrr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | Chemical Name: 2-(2-((2-chloro-6-fluorophenyl)amino)-5-methylphenyl)acetic acid InChi Key: KHPKQFYUPIUARC-UHFFFAOYSA-N InChi Code: InChI=1S/C15H13ClFNO2/c1-9-5-6-13(10(7-9)8-14(19)20)18-15-11(16)3-2-4-12(15)17/h2-7,18H,8H2,1H3,(H,19,20) SMILES Code: O=C(O)CC1=CC(C)=CC=C1NC2=C(F)C=CC=C2Cl |
| SMILES Code | O=C(O)CC1=CC(C)=CC=C1NC2=C(F)C=CC=C2Cl |
| Synonyms | Lumiracoxib; COX-189; CGS-35189; CGS 35189; COX189; CGS35189; COX 189; trade name: Prexige. |
| Protocol | In Vitro | Lumiracoxib inhibits purified COX-1 and COX-2 with Ki values of 3 μM and 0.06 μM, respectively. In cellular assays, Lumiracoxib has an IC50 of 0.14 μM in COX-2-expressing dermal fibroblasts, but causesno inhibition of COX-1 at concentrations up to 30 μM in HEK293 cells transfected with human COX-1 |
|---|---|---|
| In Vivo | Lumiracoxib (oral administration; 10 and 30 mg/kg; single dose) significantly reverses the established hyperalgesia with a maximal 58% reversal observed 3 h following administration in rat model | |
| Animal model | Rat model of bone cancer pain with injection of MRMT-1 tumour cells into one tibia | |
| Dosages | 10 and 30 mg/kg | |
| Administration | Oral administration; 10 and 30 mg/kg; twice daily; from day 10 to day 20 following MRMT-1 cell injection |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.4046 mL | 17.0230 mL | 34.0460 mL | 68.0921 mL |
| 5mM | 0.6809 mL | 3.4046 mL | 6.8092 mL | 13.6184 mL |
| 10mM | 0.3405 mL | 1.7023 mL | 3.4046 mL | 6.8092 mL |
| 20mM | 0.1702 mL | 0.8512 mL | 1.7023 mL | 3.4046 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
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V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.