Lu AF27139
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $3250 | Check With Us |
| 250mg | $5500 | Check With Us |
| 1g | $8250 | Check With Us |
: Cat #: V2508 CAS #: 2097117-06-9 Purity ≥ 99%
Description: Lu AF27139 a novel rodent-active and CNS-penetrant P2X7 receptor antagonist, which is highly selective and potent against rat, mouse, and human forms of the receptors.
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| Molecular Weight (MW) | 497.9212 |
|---|---|
| Molecular Formula | C21H19ClF3N5O2S |
| CAS No. | 2097117-06-9 |
| Synonyms | Lu AF-27139; Lu AF27139; Lu AF 27139; LuAF-27139; LuAF27139; LuAF 27139 |
| Protocol | In Vitro | Lu AF27139 (compound 1) (10-200 nM) inhibits 100 μM BzATP-induced current in HEK293 cells stably transfected with the rat P2X7R in a dose response manner with an IC50 of 66 nM |
|---|---|---|
| In Vivo | Lu AF27139 (compound 1) (p.o.; 3, 10, and 100 mg/kg) reduces intracerebroventricular (icv) administered LPS-primed and BzATP-triggered IL-1β release in the frontal cortex of rats and mice | |
| Animal model | Male Sprague−Dawley rats (280−350 g); Male C57BL mice (18−25g) | |
| Dosages | 3, 10, and 100 mg/kg |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0083 mL | 10.0417 mL | 20.0835 mL | 40.1670 mL |
| 5mM | 0.4017 mL | 2.0083 mL | 4.0167 mL | 8.0334 mL |
| 10mM | 0.2008 mL | 1.0042 mL | 2.0083 mL | 4.0167 mL |
| 20mM | 0.1004 mL | 0.5021 mL | 1.0042 mL | 2.0083 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.