lofexidine HCl

This product is for research use only, not for human use. We do not sell to patients.

lofexidine HCl
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1g$400Check With Us
2g$650Check With Us
5g$990Check With Us

Cat #: V3893 CAS #: 21498-08-8 Purity ≥ 98%

Description: Lofexidine HCl (Lucemyra) is the hydrochloride salt of lofexidine which is an analog of Clonidine and an α2A adrenergic receptor agonist.

References: Gish EC, et al. Lofexidine, an {alpha}2-receptor agonist for opioid detoxification. Ann Pharmacother. 2010 Feb;44(2):343-51.

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Product Promise

Promise
Molecular Weight (MW)295.59
Molecular FormulaC11H13Cl3N2O
CAS No.21498-08-8
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 10 mMr
Water: N/Ar
Ethanol: N/A
SMILES CodeCC(C1=NCCN1)OC2=C(C=CC=C2Cl)Cl.Cl
SynonymsLofexidine Hydrochloride; Lofetensin; Brand name Lucemyra; Lofexidine HCl; Loxacor;Lofexidine mono-hydrochloride; lofexidine (+-)-isomer
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.3831 mL16.9153 mL33.8306 mL67.6613 mL
5mM0.6766 mL3.3831 mL6.7661 mL13.5323 mL
10mM0.3383 mL1.6915 mL3.3831 mL6.7661 mL
20mM0.1692 mL0.8458 mL1.6915 mL3.3831 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.