lofexidine | CAS 31036-80-3

lofexidine

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
1g	$550	Check With Us
2g	$950	Check With Us
5g	$1440	Check With Us

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Cat #: V3894 CAS #: 31036-80-3 Purity ≥ 98%

Description: Lofexidine (Lofetensin; Loxacor; brand name Lucemyra among others), an analog of Clonidine, is a medication historically used to treat high blood pressure, but nowadays, it is more commonly used to help with the physical symptoms of opioid withdrawal.

References: Gish EC, et al. Lofexidine, an {alpha}2-receptor agonist for opioid detoxification. Ann Pharmacother. 2010 Feb;44(2):343-51.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	259.13
Molecular Formula	C11H12Cl2N2O
CAS No.	31036-80-3
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 10 mMr
	Water: N/Ar
	Ethanol: N/A
SMILES Code	CC(C1=NCCN1)OC2=C(Cl)C=CC=C2Cl
Synonyms	Brand name Lucemyra; Lofexidine HCl; Lofexidine Hydrochloride; Lofetensin; Loxacor;Lofexidine mono-hydrochloride; lofexidine (+-)-isomer

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.8591 mL	19.2953 mL	38.5907 mL	77.1813 mL
5mM	0.7718 mL	3.8591 mL	7.7181 mL	15.4363 mL
10mM	0.3859 mL	1.9295 mL	3.8591 mL	7.7181 mL
20mM	0.1930 mL	0.9648 mL	1.9295 mL	3.8591 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.