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LMPTP INHIBITOR 1 dihydrochloride

This product is for research use only, not for human use. We do not sell to patients.

LMPTP INHIBITOR 1 dihydrochloride
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Cat #: V2954 CAS #: 2310135-46-5 Purity ≥ 99%

Description: LMPTP INHIBITOR 1 is a novel and selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP)(IC50 = 0.8 μM LMPTP-A).

References: Stanford SM1, et al. Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat Chem Biol. 2017 Jun;13(6):624-632.

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Molecular Weight (MW)517.53
Molecular FormulaC28H38Cl2N4O
CAS No.2310135-46-5
SMILES CodeO=C(N(CC)CC)C1=CC=C(C2=NC3=CC=CC=C3C(NCCCN4CCCCC4)=C2)C=C1.[H]Cl.[H]Cl
SynonymsLMPTP INHIBITOR 1; LMPTP INHIBITOR 1 HCl; YUN35454; YUN-35454; YUN 35454;
ProtocolIn VitroLMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC50 of 0.8 μM LMPTP-A and shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 (Compound 23; 10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes.
In VivoLMPTP inhibitor 1 is orally bioavailable, and results in appr 680 nM mean serum concentration after treatment of 0.03% w/w, while treatment with 0.05% w/w results in >3 μM; also reverses diabetes in obese mice. LMPTP inhibitor 1 (0.05% w/w) inhibits LMPTP activity, significantly improves glucose tolerance and decreases fasting insulin levels of diabetic DIO mice, without affecting body weight.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.9323 mL9.6613 mL19.3226 mL38.6451 mL
5mM0.3865 mL1.9323 mL3.8645 mL7.7290 mL
10mM0.1932 mL0.9661 mL1.9323 mL3.8645 mL
20mM0.0966 mL0.4831 mL0.9661 mL1.9323 mL
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.