Leucovorin (Folinic acid)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $700 | Check With Us |
| 500mg | $1150 | Check With Us |
| 1g | $1725 | Check With Us |
: Cat #: V17929 CAS #: 58-05-9 Purity ≥ 98%
Description: Leucovorin (Folinic acid), the active metabolite of folic acid, is used primarily as the calcium salt form as an antidote/rescue agent to folic acid antagonists which block the conversion of folic acid to folinic acid.
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| Molecular Weight (MW) | 473.44 |
|---|---|
| Molecular Formula | C20H23N7O7 |
| CAS No. | 58-05-9 |
| SMILES Code | O=C(O)C(NC(C1=CC=C(NCC2N(C=O)C3=C(NC2)N=C(N)NC3=O)C=C1)=O)CCC(O)=O |
| Synonyms | Leucovorin; HSDB 6544 |
| Protocol | In Vitro | Methotrexate (MTX) alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) . |
|---|---|---|
| In Vivo | Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following Methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice). |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1122 mL | 10.5610 mL | 21.1220 mL | 42.2440 mL |
| 5mM | 0.4224 mL | 2.1122 mL | 4.2244 mL | 8.4488 mL |
| 10mM | 0.2112 mL | 1.0561 mL | 2.1122 mL | 4.2244 mL |
| 20mM | 0.1056 mL | 0.5281 mL | 1.0561 mL | 2.1122 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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Volume(start)
V1
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C2
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Step One: Enter information below
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Average weight of animals g
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Step Two: Enter the in vivo formulation
%DMSO
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%
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%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
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mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.