Lasofoxifene tartrate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $500 | Check With Us |
| 250mg | $900 | Check With Us |
| 500mg | $1350 | Check With Us |
: Cat #: V23768 CAS #: 190791-29-8 Purity ≥ 99%
Description: Lasofoxifene tartrate (CP336,156; CP-336,156), the tartrate salt form of Lasofoxifene, is a third-generation selective estrogen receptor modulators (SERMs).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 413.56 |
|---|---|
| Molecular Formula | C28H31NO2 |
| CAS No. | 190791-29-8 |
| Synonyms | CP-336156; Fablyn |
| Protocol | In Vivo | Lasofoxifene tartrate (4 mg/mice; s.c.; 5 day/week; for 43 d) decreases arthritis severity, by reducing cartilage oligomeric matrix protein (COMP), the serum marker of cartilage destruction and reducing serum IL-6 (inflammatory cytokine) levels |
|---|---|---|
| Animal model | Post-menopausal RA model on OVX (ovariectomised) DBA/1 mice (female DBA/1 mice, 8-10 weeks old, CIA-treated) | |
| Dosages | 4 mg/mouse/day | |
| Administration | Subcutaneous injection; 5 days a week from the first signs of arthritis (day 18); 43 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4180 mL | 12.0901 mL | 24.1803 mL | 48.3606 mL |
| 5mM | 0.4836 mL | 2.4180 mL | 4.8361 mL | 9.6721 mL |
| 10mM | 0.2418 mL | 1.2090 mL | 2.4180 mL | 4.8361 mL |
| 20mM | 0.1209 mL | 0.6045 mL | 1.2090 mL | 2.4180 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.