Laduviglusib (CHIR-99021; CT99021) HCl

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$850	Check With Us
500mg	$1250	Check With Us
1g	$1875	Check With Us

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Cat #: V2805 CAS #: 1797989-42-4 Purity ≥ 98%

Description: Laduviglusib (CHIR-99021; CT99021 or CHIR-911) HCl is the hydrochloride salt of CHIR-99021, which is a potent and orally available GSK-3α/β (glycogen synthase kinase 3α/β) inhibitor with IC50 of 10 nM/6.7 nM in cell-free assays; CHIR-99021 was proved to promote self-renewal and maintain pluripotency of both B6 and BALB/c ES cells via stabilizing the downstream effectors like c-Myc and β -catenin.

References: Ring DB, et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	501.80
Molecular Formula	C22H19Cl3N8
CAS No.	1797989-42-4
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 93 mg/mL (185.33 mM)r
	Water: <1 mg/mL (slightly soluble or insoluble)r
	Ethanol: <1 mg/mL (slightly soluble or insoluble)
SMILES Code	N#CC1=CN=C(NCCNC2=NC=C(C3=NC(C)=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2)C=C1.[H]C
Synonyms	GSK 3 inhibitor XVI; GSK 3IXV; CHIR99021; CHIR 99021; CHIR-73911 HCl; CHIR73911; CT-99021; CT- 99021; CHIR 73911 hydrochloride ; CHIR-911; CHIR911; CHIR 911; CT- 99021;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.9928 mL	9.9641 mL	19.9283 mL	39.8565 mL
5mM	0.3986 mL	1.9928 mL	3.9857 mL	7.9713 mL
10mM	0.1993 mL	0.9964 mL	1.9928 mL	3.9857 mL
20mM	0.0996 mL	0.4982 mL	0.9964 mL	1.9928 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.