L-765314
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1850 | Check With Us |
| 500mg | $2550 | Check With Us |
| 1g | $3825 | Check With Us |
: Cat #: V3338 CAS #: 189349-50-6 Purity ≥ 98%
Description: L-765314 (L-765,314) is a novel, potent and selective α1b adrenergic receptor antagonist with Kis of 5.4 nM and 2.0 nM for rat and human α1b adrenergic receptor, respectively.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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| Molecular Weight (MW) | 522.61 |
|---|---|
| Molecular Formula | C27H34N6O5 |
| CAS No. | 189349-50-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mMr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | O=C(N1[C@H](C(NC(C)(C)C)=O)CN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)OCC4=CC=CC=C4 |
| Synonyms | L-765314; L 765314; L765314 |
| Protocol | In Vitro | L-765314 shows two displacement sites. High-affinity sites account for approximately binding (IC501% of 90.25 nM, representing binding to the R1b site. Low affinity sites account for the remaining 75% of binding (IC50790 nM, representing binding to the R1a site |
|---|---|---|
| In Vivo | Plasma liquid chromatography/mass spectrometry (LCMS) analysis showed mean C for L-765314 (A322312)..maxis 1.05 μM, t1/2is 0.5 hours. L-765314 shows a weak potency (AD) to suppress the boost response to phenylephrine or A-6160325>3 mg/kg)。 Based on inhibition of the pressor response to the selective agonist A-1 of the R61603a subtype, L-765314 appears to be selective for the R1a receptor at doses up to 0.3 mg/kg. Results of antihypertensive efficacy in rats showed that both L-765314 and terazosin tended to lower heart rate (approximately 1 bpm at 25 mg/kg intravenously) |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9135 mL | 9.5674 mL | 19.1347 mL | 38.2695 mL |
| 5mM | 0.3827 mL | 1.9135 mL | 3.8269 mL | 7.6539 mL |
| 10mM | 0.1913 mL | 0.9567 mL | 1.9135 mL | 3.8269 mL |
| 20mM | 0.0957 mL | 0.4784 mL | 0.9567 mL | 1.9135 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.