KPT-185 | CAS 1333151-73-7

KPT-185

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$450	Check With Us
500mg	$750	Check With Us
1g	$1125	Check With Us

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Cat #: V1682 CAS #: 1333151-73-7 Purity ≥ 98%

Description: This product has been discontinued. KPT-185 (KPT185; KPT 185) is an irreversible and selective CRM1 (Chromosomal Maintenance 1, also known as Exportin 1 or XPO1) inhibitor with potential antitumor activity.

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Physicochemical and Storage Information
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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	355.31
Molecular Formula	C16H16F3N3O3
CAS No.	1333151-73-7
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 71 mg/mL (199.8 mM)r
	Water: <1 mg/mLr
	Ethanol: 71 mg/mL (199.8 mM)
Solubility In Vivo	N/A
Synonyms	KPT-185; KPT185; KPT 185

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.8144 mL	14.0722 mL	28.1444 mL	56.2889 mL
5mM	0.5629 mL	2.8144 mL	5.6289 mL	11.2578 mL
10mM	0.2814 mL	1.4072 mL	2.8144 mL	5.6289 mL
20mM	0.1407 mL	0.7036 mL	1.4072 mL	2.8144 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.