IWP-2
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $600 | In Stock |
| 500mg | $960 | In Stock |
| 1g | $1440 | In Stock |
: Cat #: V1355 CAS #: 686770-61-6 Purity ≥ 98%
Description: IWP-2 (IWP 2, IWP2) is a novel and potent inhibitor of Wnt processing and secretion (specifically, Porcn-mediated Wnt palmitoylation) with potential antineoplastic activity.
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- Physicochemical and Storage Information
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| Molecular Weight (MW) | 466.6 |
|---|---|
| Molecular Formula | C22H18N4O2S3 |
| CAS No. | 686770-61-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 4 mg/mL (8.6 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: N/A | |
| Synonyms | IWP 2, IWP-2, IWP2 |
| Protocol | In Vitro | IWP-2 inhibits the proliferation of the investigated cell lines within the single digit μM range. IWP-2 inhibits cell proliferation in A818-6, MiaPaCa2, Panc-1, Panc-89, HT29, HEK293, SW620 and Capan cell with EC50s of 8.96 μM, 1.90 μM, 2.33 μM, 3.86 μM, 4.67 μM, 2.76 μM, 1.90 μM and 2.05 μM, respectively |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1432 mL | 10.7158 mL | 21.4316 mL | 42.8633 mL |
| 5mM | 0.4286 mL | 2.1432 mL | 4.2863 mL | 8.5727 mL |
| 10mM | 0.2143 mL | 1.0716 mL | 2.1432 mL | 4.2863 mL |
| 20mM | 0.1072 mL | 0.5358 mL | 1.0716 mL | 2.1432 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.