Ivabradine HCl (Procoralan)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $520 | Check With Us |
| 500mg | $850 | Check With Us |
| 1g | $1275 | Check With Us |
: Cat #: V1142 CAS #: 148849-67-6 Purity ≥ 98%
Description: Ivabradine HCl (Corlentor; Corlanor; Coraxan; Ivabid; Procoralan; Coralan; S16257; S 16257; S-16257; Bradia), the hydrochloride salt of Ivabradine, is a novel and potent cardiac pacemaker current (If) inhibitor with antianginal effects.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 505.05 |
|---|---|
| Molecular Formula | C27H36N2O5.HCl |
| CAS No. | 148849-67-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 101 mg/mL (200 mM)r |
| Water: 82 mg/mL (162.4 mM)r | |
| Ethanol: 101 mg/mL (200 mM) | |
| Synonyms | S 16257-2; Corlanor; S-16257-2; Coraxan; Ivabid; S16257-2; Ivabradine HCl; Corlentor; Procoralan; Coralan; Bradia. |
| Protocol | In Vivo | Ivabradine hydrochloride (1, 10, 20 mg/kg; i.p.) shows anticonvulsant and neuroprotective action in mice |
|---|---|---|
| Animal model | 25-30 g, 6 weeks male Swiss mice | |
| Dosages | 1, 10, 20 mg/kg | |
| Administration | I.p.; for 3 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9800 mL | 9.9000 mL | 19.8000 mL | 39.6000 mL |
| 5mM | 0.3960 mL | 1.9800 mL | 3.9600 mL | 7.9200 mL |
| 10mM | 0.1980 mL | 0.9900 mL | 1.9800 mL | 3.9600 mL |
| 20mM | 0.0990 mL | 0.4950 mL | 0.9900 mL | 1.9800 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.