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Isoprenaline HCl (Isoproterenol HCl)

This product is for research use only, not for human use. We do not sell to patients.

Isoprenaline HCl (Isoproterenol HCl)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5g$125Check With Us
10g$220Check With Us
20g$330Check With Us
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Cat #: V1119 CAS #: 51-30-9 Purity ≥ 98%

Description: Isoprenaline HCL (NCIc55630; NCI c55630; Isoproterenol), the hydrochloride salt of Isoprenaline, is a non-selective beta-adrenergic receptor agonist that has been used for the treatment of bradycardia and heart block.

References: Degerman E, et al. Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylation. Proc Natl Acad Sci U S A. 1990 Jan;87(2):533-7

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Molecular Weight (MW)247.72
Molecular FormulaC11H17NO3.HCl
CAS No.51-30-9
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 50 mg/mL (201.8 mM)r
Water: 50 mg/mL (201.8 mM)r
Ethanol: <1 mg/mL
Solubility In VivoChemical Name: 4-[(1R)-1-Hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol;hydrochloride InChi Key: IROWCYIEJAOFOW-MERQFXBCSA-N InChi Code: InChI=1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H/t11-;/m0./s1 SMILES Code: OC1=CC=C([C@@H](O)CNC(C)C)C=C1O.[H]Cl
SynonymsNCI-c55630; Isoprenaline hydrochloride; NCIc55630; NCI c55630; Isoproterenol
ProtocolIn VitroIsoprenaline (Isoproterenol) hydrochloride (300 nM, 3 min) increases particulate cGMP- and cilostamide-inhibited, low-Km cAMP phosphodiesterase (cAMP-PDE) activity by about 100% in intact rat fat cells
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM4.0368 mL20.1841 mL40.3682 mL80.7363 mL
5mM0.8074 mL4.0368 mL8.0736 mL16.1473 mL
10mM0.4037 mL2.0184 mL4.0368 mL8.0736 mL
20mM0.2018 mL1.0092 mL2.0184 mL4.0368 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.