ISLATRAVIR
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $3000 | In Stock |
| 200mg | $4500 | In Stock |
| 500mg | $7590 | In Stock |
: Cat #: V4389 CAS #: 865363-93-5 Purity ≥ 98%
Description: Islatravir (formerly known as MK-8591; 4′-ethynyl-2-fluoro-2′-deoxyadenosine; EFdA; ISL) is a novel and potent anti-HIV-1 agent which acts as an NRTTI (nucleoside reverse transcriptase inhibitor) with anti-HIV activities.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 293.2584 |
|---|---|
| Molecular Formula | C12H12FN5O3 |
| CAS No. | 865363-93-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | NC1=C(N=CN2[C@H]3C[C@@H]([C@@](O3)(C#C)CO)O)C2=NC(F)=N1 |
| Synonyms | MK-8591; 4′-ethynyl-2-fluoro-2′-deoxyadenosine; EFdA; ISL; MK8591; MK 8591 |
| Protocol | In Vitro | slatravir (MK-8591) (4'Ed2FA) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.4100 mL | 17.0498 mL | 34.0996 mL | 68.1992 mL |
| 5mM | 0.6820 mL | 3.4100 mL | 6.8199 mL | 13.6398 mL |
| 10mM | 0.3410 mL | 1.7050 mL | 3.4100 mL | 6.8199 mL |
| 20mM | 0.1705 mL | 0.8525 mL | 1.7050 mL | 3.4100 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.