RN-18 is an HIV-1 Vif inhibitor.

(S)-Tenofovir [known also as (S)-GS 1278], the S-enantiomer of Tenofovir and a less active isomer, is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B (HBV).

9-Propenyladenine is an impurity found in tenofovir disoproxil fumarate with mutagenicity.

Fosamprenavir (also known as GW433908; Amprenavir phosphate; GW-433908) is a phosphate ester prodrug of Amprenavir with improved solubility and antiviral effects.

Temsavir (formerly known as BMS626529; BMS-626529) is a novel, potent attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells. Temsavir is also the phosphonooxymethyl prodrug of BMS-626529 that targets HIV-1 gp120 and prevents its binding to CD4(+) T cells. BMS-626529 had half-maximal effective concentration (EC(50)) values of<10 nm, with half-maximal […]

Fostemsavir (BMS-663068; BMS663068; Rukobia), the phosphonooxymethyl prodrug of BMS-626529, is an approved (in 2020) antiretroviral medication for adults living with HIV/AIDS. It is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells. The activity of BMS-626529 is virus dependent, due to heterogeneity within gp120. In order to better […]

Dolutegravir intermediate-1 is an intermediate to the synthesis of dolutegravir which is an HIV integrase inhibitor for the treatment of human immunodeficiency virus (HIV)-l infection.

Doravirine (formerly known as MK-1439 and DOR; trade name: Pifeltro) is a novel human immunodeficiency type 1 virus (HIV-1) nonnucleoside reverse transcriptase inhibitor (NNRTI) that is approved in August 2018 to treat HIV-1 infection in adult patients. Doravirine exhibits potent antiviral activity against wild-type virus and K103N, Y181C, and K103N/Y181C mutant viruses, with 50% inhibitory […]

Apricitabine [(-)-BCH-10652; (-)-dOTC; AVX-754; BCH-10618; SPD-754] is a highly potent, selective and orally bioactive HIV-1 reverse transcriptase (RT) inhibitor with Ki of 0.08 μM, belonging to the nucleoside reverse transcriptase inhibitor (NRTI) class of anti-HIV agents.

Tenofovir exalidex (formerly known as HDP-Tenofovir and CMX-157) is a novel and potent lipophilic / acyclic nucleoside phosphonate that is able to deliver high concentrations of the active antiviral agent tenofovir to target cells.