Iptacopan (LNP023) hydrochloride
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $2300 | Check With Us |
| 200mg | $3450 | Check With Us |
| 500mg | $5820 | Check With Us |
: Cat #: V2514 CAS #: 1646321-63-2 Purity ≥ 99%
Description: Iptacopan (LNP-023; LNP023) HCl, the hydrochloride salt of Iptacopan, is an oral, potent and selective factor B inhibitor ( IC50 = 10 nM).
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| Molecular Weight (MW) | 458.98 |
|---|---|
| Molecular Formula | C25H31ClN2O4 |
| CAS No. | 1646321-63-2 |
| SMILES Code | O=C(O)C1=CC=C([C@H]2N(CC3=C(OC)C=C(C)C4=C3C=CN4)CC[C@H](OCC)C2)C=C1.[H]Cl |
| Synonyms | LNP023; LNP-023; LNP 023; Ipatacopan; Iptacopan hydrochloride; |
| Protocol | In Vitro | LNP023 demonstrates potent inhibition of alternative complement pathway (AP)-induced membrane attack complex (MAC) formation in 50% human serum (IC50 value of 130 nM). |
|---|---|---|
| In Vivo | LNP023 (20-180 mg/kg; oral administration) prevents KRN (150 μL)-induced arthritis in mice and is effective upon prophylactic and therapeutic dosing in an experimental model of membranous nephropathy in rats. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1787 mL | 10.8937 mL | 21.7874 mL | 43.5749 mL |
| 5mM | 0.4357 mL | 2.1787 mL | 4.3575 mL | 8.7150 mL |
| 10mM | 0.2179 mL | 1.0894 mL | 2.1787 mL | 4.3575 mL |
| 20mM | 0.1089 mL | 0.5447 mL | 1.0894 mL | 2.1787 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.