INVIVO-4823
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1550 | Check With Us |
| 500mg | $2050 | Check With Us |
| 1g | $3075 | Check With Us |
: Cat #: V25175 CAS #: 1908414-82-3 Purity ≥ 99%
Description: INVIVO-4823, formerly known as LMPTP inhibitor1; is a potent inhibitor of the low-molecular-weight tyrosine phosphatase (LMPTP).
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| Molecular Weight (MW) | 444.61 |
|---|---|
| Molecular Formula | C28H36N4O |
| CAS No. | 1908414-82-3 |
| SMILES Code | O=C(N(CC)CC)C1=CC=C(C2=NC3=CC=CC=C3C(NCCCN4CCCCC4)=C2)C=C1 |
| Synonyms | MDK-4823; MDK 4823; MDK4823; LMPTP inhibitor1; LMPTP inhibitor-1; LMPTP-IN-23; LMPTP-IN 23; LMPTP-IN23; |
| Protocol | In Vitro | LMPTP inhibitor 1 (Compound 23) is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC50 of 0.8 μM LMPTP-A and shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 (10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes. |
|---|---|---|
| In Vivo | LMPTP inhibitor 1 is orally bioavailable, and results in appr 680 nM mean serum concentration after treatment of 0.03% w/w, while treatment with 0.05% w/w results in >3 μM; also reverses diabetes in obese mice. LMPTP inhibitor 1 (0.05% w/w) inhibits LMPTP activity, significantly improves glucose tolerance and decreases fasting insulin levels of diabetic DIO mice, without affecting body weight. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2492 mL | 11.2458 mL | 22.4916 mL | 44.9832 mL |
| 5mM | 0.4498 mL | 2.2492 mL | 4.4983 mL | 8.9966 mL |
| 10mM | 0.2249 mL | 1.1246 mL | 2.2492 mL | 4.4983 mL |
| 20mM | 0.1125 mL | 0.5623 mL | 1.1246 mL | 2.2492 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.