Intepirdine (SB-742457; GSK-742457; RVT-101)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1350 | Check With Us |
| 1g | $2150 | Check With Us |
| 5g | $5370 | Check With Us |
: Cat #: V1020 CAS #: 607742-69-8 Purity ≥ 98%
Description: Intepirdine (formerly GSK-742457; RVT-101; SB742457; SB 742457; GSK742457; SB-742457; RVT 101) is a potent and highly selective 5-HT6 receptor antagonist with potential cognition, memory, and learning-enhancing effects.
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| Molecular Weight (MW) | 353.44 |
|---|---|
| Molecular Formula | C19H19N3O2S |
| CAS No. | 607742-69-8 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 78 mg/mL (220.7 mM)rr |
| Water: <1 mg/mLrr | |
| Ethanol: 2 mg/mL (5.7 mM) | |
| Solubility In Vivo | 2% DMSO, 48% PEG300, 2% Tween 80 and 48% water: 5mg/mL |
| Synonyms | GSK 742457; GSK-742457; RVT-101; SB742457; SB 742457; GSK742457; SB-742457; RVT 101; RVT101 |
| Protocol | In Vitro | Intepirdine (SB742457), a 5-HT6 receptor antagonist, which extends into Alzheimer disease (AD) sufferers further highlights the therapeutic promise of this mechanistic approach. Alzheimer's disease is a devastating neurological condition characterized by a progressive decline in cognitive performance accompanied by behavioral and psychological syndromes, such as depression and psychosis. With the subsequent development of selective 5-HT6 receptor antagonists, preclinical studies in rodents and primates have elucidated the function of this receptor subtype in more detail. It is increasingly clear that blockade of 5-HT6 receptors leads to an improvement of cognitive performance in a wide variety of learning and memory paradigms and also results in anxiolytic and antidepressant-like activity. Intepirdine (SB742457) is generally safe and well tolerated and may be efficacious in Alzheimer disease. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8293 mL | 14.1467 mL | 28.2933 mL | 56.5867 mL |
| 5mM | 0.5659 mL | 2.8293 mL | 5.6587 mL | 11.3173 mL |
| 10mM | 0.2829 mL | 1.4147 mL | 2.8293 mL | 5.6587 mL |
| 20mM | 0.1415 mL | 0.7073 mL | 1.4147 mL | 2.8293 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.