inS3-54-A18
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1600 | To Be Confirmed |
| 200mg | $2400 | To Be Confirmed |
| 500mg | $4050 | To Be Confirmed |
: Cat #: V22577 CAS #: 328998-53-4 Purity ≥ 98%
Description: inS3-54-A18 is a STAT3 inhibitor, suppressing tumor growth, metastasis and STAT3 target gene expression in vivo.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 373.83 |
|---|---|
| Molecular Formula | C23H16ClNO2 |
| CAS No. | 328998-53-4 |
| SMILES Code | O=C1N(C2=CC=C(O)C=C2)C(C3=CC=CC=C3)=C/C1=C/C4=CC=C(Cl)C=C4 |
| Synonyms | inS3-54-A18; inS3-54A18; inS3-54 A18; inS354-A18; inS354 A18; inS354A18; |
| Protocol | In Vitro | inS3-54A18 (5 μM) reduces wound healing to 64% and 76% for A549 and MDA-MB-231 cells, respectively. inS3-54A18 at 10 μM further reduces the healing to 47% and 39%, respectively. inS3-54A18 inhibits the expression of STAT3 downstream target genes and the binding of STAT3 to its endogenous target sequences. inS3-54A18 does not affect the constitutive or IL-6-induced STAT3 activation (Tyr705 phosphorylation) but represses STAT3 target gene (survivin) expression. |
|---|---|---|
| In Vivo | inS3-54A18 (200 mg/kg, p.o.) inhibits tumor growth, metastasis and expression of STAT3 target genes in a mouse xenograft model of A549 cells. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6750 mL | 13.3751 mL | 26.7501 mL | 53.5003 mL |
| 5mM | 0.5350 mL | 2.6750 mL | 5.3500 mL | 10.7001 mL |
| 10mM | 0.2675 mL | 1.3375 mL | 2.6750 mL | 5.3500 mL |
| 20mM | 0.1338 mL | 0.6688 mL | 1.3375 mL | 2.6750 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.