Indoximod (NLG 8189)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $290 | Check With Us |
| 5g | $550 | Check With Us |
| 10g | $825 | Check With Us |
: Cat #: V0941 CAS #: 110117-83-4 Purity ≥ 98%
Description: Indoximod (NLG-8189; 1-Methyl-D-tryptophan; Indoximod; NLG8189; D1MT) is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with potential immunomodulating and antitumor activity.
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| Molecular Weight (MW) | 218.25 |
|---|---|
| Molecular Formula | C12H14N2O2 |
| CAS No. | 110117-83-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 1 mg/mL (4.6 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| SMILES Code | N[C@H](CC1=CN(C)C2=CC=CC=C12)C(O)=O |
| Synonyms | NLG 8189; 1-Methyl-D-tryptophan; Indoximod; NLG8189; NLG-8189; D1MT; |
| Protocol | In Vitro | The IDO inhibitor 1-methyl-tryptophan exists in two stereoisomers with potentially different biological properties. The L isomer is the more potent inhibitor of IDO activity using the purified enzyme and in HeLa cell–based assays. However, the D isomer is significantly more effective in reversing the suppression of T cells created by IDO-expressing dendritic cells. The L isomer of 1-methyl-tryptophan functioned as a competitive inhibitor (Ki=19 μM), whereas the d isomer is much less effective. The DL mixture is intermediate, with a Ki of 35 μM. |
|---|---|---|
| In Vivo | The D isomer is more efficacious as an anticancer agent in chemo-immunotherapy regimens using NSC-26271, NSC 125973, or LY 188011, when tested in mouse models of transplantable melanoma and transplantable and autochthonous breast cancer. The D isomer of 1-methyl-tryptophan specifically targets the IDO gene because the antitumor effect of d-1-methyl-tryptophan is completely lost in mice with a disruption of the IDO gene (IDO-knockout mice). Oral administration of dl-1-methyl-tryptophan in combination with NSC 125973 can elicit regression of autochthonous breast tumors. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.5819 mL | 22.9095 mL | 45.8190 mL | 91.6380 mL |
| 5mM | 0.9164 mL | 4.5819 mL | 9.1638 mL | 18.3276 mL |
| 10mM | 0.4582 mL | 2.2910 mL | 4.5819 mL | 9.1638 mL |
| 20mM | 0.2291 mL | 1.1455 mL | 2.2910 mL | 4.5819 mL |
The molarity calculator equation
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The dilution calculator equation
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Step Two: Enter the in vivo formulation
%DMSO
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Method for preparing DMSO master liquid:
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.