Indomethacin (Indometacin)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50g | $400 | Check With Us |
| 100g | $560 | Check With Us |
| 200g | $840 | Check With Us |
: Cat #: V1041 CAS #: 53-86-1 Purity ≥ 98%
Description: Indomethacin (Indometacin; Indocin) is a potent and non-selective COX1 and COX2 inhibitor of the nonsteroidal anti-inflammatory drug (NSAID) class with an IC50 of 0.1 μg/mL and 5 μg/mL, respectively.
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- Protocol
- Related Biological Data
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| Molecular Weight (MW) | 357.79 |
|---|---|
| Molecular Formula | C19H16ClNO4 |
| CAS No. | 53-86-1 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 72 mg/mL (201.2 mM)rr |
| Water: <1 mg/mLrr | |
| Ethanol: 24 mg/mL (67.1 mM) | |
| Synonyms | Indometacin; Indocin. |
| Protocol | In Vitro | Indomethacin (Indometacin) (0-150 μM; 24 hours; 3LL-D122 cells) has anticancer activity in vitro |
|---|---|---|
| In Vivo | Indomethacin (Indometacin) (10 mg/mL; p.o.; daily, for 29 days; male C57BL/6J mice) inhibits tumor growth in vivo |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7949 mL | 13.9747 mL | 27.9494 mL | 55.8987 mL |
| 5mM | 0.5590 mL | 2.7949 mL | 5.5899 mL | 11.1797 mL |
| 10mM | 0.2795 mL | 1.3975 mL | 2.7949 mL | 5.5899 mL |
| 20mM | 0.1397 mL | 0.6987 mL | 1.3975 mL | 2.7949 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.