Indinavir sulfate

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$180	Check With Us
2g	$280	Check With Us
5g	$470	Check With Us

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Cat #: V4109 CAS #: 157810-81-6 Purity ≥ 98%

Description: Indinavir sulfate (IDV; formerly known as MK-639; DRG-0233; L735524; trade name Crixivan), the sulfate salt of indinavir, is a potent and specific HIV protease inhibitor with antiviral effects and good oral bioavailability.

References: Chavan S, et al. The HIV protease inhibitor Indinavir inhibits cell-cycle progression in vitro in lymphocytes of HIV-infected and uninfected individuals. Blood. 2001 Jul 15;98(2):383-9.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	711.87
Molecular Formula	C36H49N5O8S
CAS No.	157810-81-6
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: ≥ 100 mg/mLr
	Water: 50 mg/mLr
	Ethanol: N/N
SMILES Code	O=C([C@H]1N(C[C@@H](O)C[C@@H](CC2=CC=CC=C2)C(N[C@@H]3[C@H](O)CC4=C3C=CC=C4)=O)CCN(CC5=CC=CN=C5)C1)NC(C)(C)C.O=S(O)(O)=O
Synonyms	Indinavir sulfate, trade name: Crixivan; DRG-0233; DRG0233; L-735 524 sulfate; DRG 0233; MK-639 sulfate; L 735 524; MK 639; L735 524; MK639;

Related Biological Data

Protease-inhibitor interactions. J Mol Biol. 2005 Dec 9;354(4):789-800.

The catalytic site of PRL24I–p2/NC at 1.1 Å resolution.J Mol Biol. 2005 Dec 9;354(4):789-800.

Structural differences at sites of mutation. J Mol Biol. 2005 Dec 9;354(4):789-800.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.4048 mL	7.0238 mL	14.0475 mL	28.0950 mL
5mM	0.2810 mL	1.4048 mL	2.8095 mL	5.6190 mL
10mM	0.1405 mL	0.7024 mL	1.4048 mL	2.8095 mL
20mM	0.0702 mL	0.3512 mL	0.7024 mL	1.4048 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.