Imiquimod
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $150 | Check With Us |
| 5g | $230 | Check With Us |
| 10g | $345 | Check With Us |
: Cat #: V3267 CAS #: 99011-02-6 Purity ≥ 98%
Description: Imiquimod (S-26308; R-837; TMX-101; Aldara; Zyclara) is an immune response modifier that acts as an agonist of the TLR7 (toll-like receptor 7).
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| Molecular Weight (MW) | 240.3 |
|---|---|
| Molecular Formula | C14H16N4 |
| CAS No. | 99011-02-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 2.4 mg/mLr |
| Water: NAr | |
| Ethanol: NA | |
| SMILES Code | NC1=NC2=CC=CC=C2C3=C1N=CN3CC(C)C |
| Synonyms | S26308; R 837; TMX-101; S 26308; R837; TMX 101; S-26308; R837; TMX101; Brand names: Aldara; Zyclara; Vyloma; Beselna. |
| Protocol | In Vivo | In animal models, Imiquimod stimulates the innate immune response by increasing NK cell activity, activating macrophages to secrete cytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumour necrosis factor (TNF)-α. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.1615 mL | 20.8073 mL | 41.6146 mL | 83.2293 mL |
| 5mM | 0.8323 mL | 4.1615 mL | 8.3229 mL | 16.6459 mL |
| 10mM | 0.4161 mL | 2.0807 mL | 4.1615 mL | 8.3229 mL |
| 20mM | 0.2081 mL | 1.0404 mL | 2.0807 mL | 4.1615 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.