IDO-IN-2
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1150 | In Stock |
| 500mg | $1750 | In Stock |
| 1g | $2625 | In Stock |
: Cat #: V3146 CAS #: 1668565-74-9 Purity ≥ 98%
Description: IDO inhibitor 1 (IDO-IN-2) is a novel and potent small molecule inhibitor of the IDO enzyme (indoleamine-(2,3)-dioxygenase) with an IC50 of 3 nM in cell free assays, and IC50 values of 0.068 μM in HeLa cell and 0.16 μM in HEK293 cell.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 497.63 |
|---|---|
| Molecular Formula | C29H35N7O |
| CAS No. | 1668565-74-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: >30 mg/mLr |
| Water: N/Ar | |
| Ethanol: | |
| SMILES Code | O=C(NC1=CC=C(C)C=C1)NC2=CC(C3=CC=CC=C3C4=NNN=N4)=CC=C2N(CC(C)C)CC(C)C |
| Synonyms | IDO IN-2; IDOIN-2; IDO-IN2; IDO IN 2; IDO-IN-2, IDO inhibitor 1; |
| Protocol | In Vitro | PCC0208009 inhibits IDO1 activity in HeLa cells, with an IC50 value of 4.52 nM, but it does not change the enzyme activity in vitro, indicating that it acts as an indirect IDO1 inhibitor. |
|---|---|---|
| In Vivo | PCC0208009 (oral gavage; once; 12-50 mg/kg) in adult male Sprague Dawley rats (180 g-200 g) is detected at 30, 60 and 90min after administration to evaluate the antinociceptive effects of PCC0208009 on neuropathic pain. PCC0208009 (single oral gavage; 50 mg/kg) in adult male Sprague Dawley rats (180 g-200 g) is detected at 60, 120 and 240 min after drug administration in plasma and brain samples, and the highest concentrations of PCC0208009 in plasma and brain are observed at 60 min after administration. Concomitantly, the Kyn/Trp ratio decreases at 60, 120 and 240 min postdose, with the minimum level in the plasma and the brain seen at 60 min post-dose. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0095 mL | 10.0476 mL | 20.0953 mL | 40.1905 mL |
| 5mM | 0.4019 mL | 2.0095 mL | 4.0191 mL | 8.0381 mL |
| 10mM | 0.2010 mL | 1.0048 mL | 2.0095 mL | 4.0191 mL |
| 20mM | 0.1005 mL | 0.5024 mL | 1.0048 mL | 2.0095 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.