ICA-27243
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $950 | Check With Us |
| 500mg | $1600 | Check With Us |
| 1g | $2400 | Check With Us |
: Cat #: V18321 CAS #: 325457-89-4 Purity ≥ 99%
Description: ICA-27243 is a novel and potent activator of M-current and KCNQ2/Q3 channels
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| Molecular Weight (MW) | 268.65 |
|---|---|
| Molecular Formula | C12H7ClF2N2O |
| CAS No. | 325457-89-4 |
| Synonyms | ICA27243; ICA 27243 |
| Protocol | In Vitro | In SH-SY5Y human neuroblastoma cells, ICA-27243 produces membrane potential hyperpolarization that could be prevented by coadministration with the M-current inhibitors XE-991 and Linopirdine. ICA-27243 enhances both 86Rb+ efflux (EC50 = 0.2 μM) and whole-cell currents in Chinese hamster ovary cells stably expressing heteromultimeric KCNQ2/Q3 channels (EC50 = 0.4 μM). Activation of KCNQ2/Q3 channels is associated with a hyperpolarizing shift of the voltage dependence of channel activation (V1/2 shift of -19 mV at 10 μM) |
|---|---|---|
| In Vivo | ICA-27243 (1-100 mg/kg; oral administration; male CD-1 mice) has anticonvulsant activity (ED50 of 8.4 mg/kg) in the mouse maximal electroshock epilepsy model | |
| Animal model | Male CD-1 mice with electroshock assay | |
| Dosages | 1-100 mg/kg | |
| Administration | Oral administration |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.7223 mL | 18.6116 mL | 37.2232 mL | 74.4463 mL |
| 5mM | 0.7445 mL | 3.7223 mL | 7.4446 mL | 14.8893 mL |
| 10mM | 0.3722 mL | 1.8612 mL | 3.7223 mL | 7.4446 mL |
| 20mM | 0.1861 mL | 0.9306 mL | 1.8612 mL | 3.7223 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.