This product is for research use only, not for human use. We do not sell to patients.
| Size | Price | Stock |
|---|---|---|
| 5mg | $70 | 3-6 Days |
| 10mg | $100 | 3-6 Days |
| 25mg | $150 | 3-6 Days |
| 50mg | $250 | 3-6 Days |
| 100mg | $420 | 3-6 Days |
| 250mg | $720 | 3-6 Days |
| 500mg | $1220 | 3-6 Days |
: Cat #: V2911 CAS #: 1453097-13-6 Purity ≥ 98%
Description: HUHS015 is a novel and potent inhibitor of PCA-1/ALKBH3 (prostate cancer antigen-1/AlkB Homolog 3) both in vitro and in vivo that was discovered from the optimization of a hit compound identified during random screening using a recombinant PCA-1/ALKBH3. The bioavailability (BA) of HUHS015 was 7.2% in rats after oral administration. Continuously administering HUHS015 significantly suppressed the growth of DU145 cells, which are human hormone-independent prostate cancer cells, in a mouse xenograft model without untoward effects.
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 318.37 |
|---|---|
| Molecular Formula | C19H18N4O |
| CAS No. | 1453097-13-6 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 34 mg/mL |
| Water: <1 mg/mL | |
| Ethanol: | |
| SMILES Code | OC1=C(CC2=CC=CC=C2)C(C)=NN1C3=NC4=CC(C)=CC=C4N3 |
| Synonyms | HUHS015; HUHS 015; HUHS-015 |
| Protocol | In Vitro | In vitro activity: HUHS015 is a novel and potent inhibitor of PCA-1/ALKBH3 (prostate cancer antigen-1/AlkB Homolog 3) both in vitro and in vivo that was discovered from the optimization of a hit compound identified during random screening using a recombinant PCA-1/ALKBH3. The bioavailability (BA) of HUHS015 was 7.2% in rats after oral administration. Continuously administering HUHS015 significantly suppressed the growth of DU145 cells, which are human hormone-independent prostate cancer cells, in a mouse xenograft model without untoward effects. Kinase Assay: Cell Assay: |
|---|---|---|
| In Vivo | HUHS015 significantly suppressed the growth of DU145 cells, which are human hormone-independent prostate cancer cells, in a mouse xenograft model without untoward effects. | |
| Animal model | Mouse xenograft model |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.1410 mL | 15.7050 mL | 31.4100 mL | 62.8200 mL |
| 5mM | 0.6282 mL | 3.1410 mL | 6.2820 mL | 12.5640 mL |
| 10mM | 0.3141 mL | 1.5705 mL | 3.1410 mL | 6.2820 mL |
| 20mM | 0.1570 mL | 0.7852 mL | 1.5705 mL | 3.1410 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.