HO-3867

This product is for research use only, not for human use. We do not sell to patients.

HO-3867
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1340To Be Confirmed
500mg$1950To Be Confirmed
1g$2925To Be Confirmed

Cat #: V1384 CAS #: 1172133-28-6 Purity ≥ 98%

Description: HO-3867 (HO3867; HO 3867), an analog of curcumin, is a novel, selective and potent STAT3 inhibitor with potential antitumor activity.

References: Rath KS et al. HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer. Cancer Res. 2014 Apr 15;74(8):2316-27.

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Product Promise

Promise
Molecular Weight (MW)464.55
Molecular FormulaC28H30F2N2O2
CAS No.1172133-28-6
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 13 mg/mL (28.0 mM)r
Water: <1 mg/mLr
Ethanol: 6 mg/mL (12.9 mM)
SynonymsHO3867; HO 3867; HO-3867
ProtocolIn VitroHO-3867 exhibit minimal toxicity toward noncancerous cells and tissues but induce apoptosis in ovarian cancer cells.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.1526 mL10.7631 mL21.5262 mL43.0524 mL
5mM0.4305 mL2.1526 mL4.3052 mL8.6105 mL
10mM0.2153 mL1.0763 mL2.1526 mL4.3052 mL
20mM0.1076 mL0.5382 mL1.0763 mL2.1526 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.