Hexestrol (HSDB 2149)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $150 | Check With Us |
| 5g | $405 | Check With Us |
| 10g | $605 | Check With Us |
: Cat #: V1731 CAS #: 84-16-2 Purity ≥ 98%
Description: Hexestrol (formerly HSDB2149; HSDB-2149; Cycloestrol; Hexoestrol; Erythrohexestrol; Sinestrol) is a synthetic ER (estrogen receptor) agonist which binds to ERα and ERβ with EC50s of 0.07 nM and 0.175 nM, respectively.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 270.37 |
|---|---|
| Molecular Formula | C18H22O2 |
| CAS No. | 84-16-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 42 mg/mL (155.3 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 42 mg/mL (155.3 mM) | |
| Solubility In Vivo | 30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL |
| Synonyms | HSDB 2149; Cycloestrol; Erythrohexestrol; HSDB2149; HSDB-2149; Hexoestrol; Sinestrol |
| Protocol | In Vivo | Hexestrol (3 and 6 mg/kg; i.p. once daily for 30 days) has a not significant influence in the ovaries from mice at the dose of 3 mg/kg |
|---|---|---|
| Animal model | Mus musculus (90-120 days, 25-50 g) | |
| Dosages | 3, 6 mg/kg (adopted the same dose used to increase weight gain in cattle) | |
| Administration | I.p. once daily for 30 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.6986 mL | 18.4932 mL | 36.9864 mL | 73.9727 mL |
| 5mM | 0.7397 mL | 3.6986 mL | 7.3973 mL | 14.7945 mL |
| 10mM | 0.3699 mL | 1.8493 mL | 3.6986 mL | 7.3973 mL |
| 20mM | 0.1849 mL | 0.9247 mL | 1.8493 mL | 3.6986 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.