H 151 (H-151)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$850	Check With Us
500mg	$1350	Check With Us
1g	$2025	Check With Us

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Cat #: V22028 CAS #: 941987-60-6 Purity ≥ 98%

Description: H151 (H-151) is a potent, selective and irreversible STING antagonist/inhibitor with the potential to be used for autoimmune diseases such as arthritis and other inflammatory conditions.

References: Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	279.34
Molecular Formula	C17H17N3O
CAS No.	941987-60-6
SMILES Code	O=C(NC1=CNC2=C1C=CC=C2)NC3=CC=C(CC)C=C3
Synonyms	H 151; H-151; H151;

Protocol	In Vitro	H-151 (1 μM; 3 h) suppresses hsSTING palmitoylation. H-151 (0.5 μM; 2 h) inhibits the phosphorylation of TBK1 in THP-1 cells. H-151 (0.02-2 μM) reduces IFNβ luciferase reporter measurements of HEK293T cells.
Protocol	In Vivo	H-151 (750 nmol per mouse; i.p.) reaches effective systemic levels, displays a short half-life in the serum and forms an adduct to mmSTING in wild-type mice. H-151 (750 nmol per mouse; i.p. daily for 7 d) exhibits notable efficacy in Trex1−/− mice that expressed a bioluminescent IFNβ reporter. H-151 (750 nmol per mouse; a single i.p.) markedly reduces systemic cytokine responses in CMA-treated mice.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.5799 mL	17.8993 mL	35.7987 mL	71.5973 mL
5mM	0.7160 mL	3.5799 mL	7.1597 mL	14.3195 mL
10mM	0.3580 mL	1.7899 mL	3.5799 mL	7.1597 mL
20mM	0.1790 mL	0.8950 mL	1.7899 mL	3.5799 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.