GW4064
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $750 | To Be Confirmed |
| 500mg | $1250 | To Be Confirmed |
| 1g | $1875 | To Be Confirmed |
: Cat #: V1841 CAS #: 278779-30-9 Purity ≥ 98%
Description: GW4064 (GW-4064) is a novel, potent and selective agonist of farnesoid X receptor (FXR) (EC50 of 65 nM in CV1 cell line) with potential usefulness in the treatment of cholestatic liver disease.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 542.84 |
|---|---|
| Molecular Formula | C28H22Cl3NO4 |
| CAS No. | 278779-30-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (184.2 mM)r |
| Water: <1 mg/mLr | |
| Ethanol:<1 mg/mL | |
| Solubility In Vivo | 0.5% methylcellulose: 11 mg/mL |
| SMILES Code | O=C(O)C1=CC=CC(/C=C/C2=CC=C(OCC3=C(C(C)C)ON=C3C4=C(Cl)C=CC=C4Cl)C=C2Cl)=C1 |
| Synonyms | GW-4064; GW4064; GW 4064 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8422 mL | 9.2108 mL | 18.4216 mL | 36.8433 mL |
| 5mM | 0.3684 mL | 1.8422 mL | 3.6843 mL | 7.3687 mL |
| 10mM | 0.1842 mL | 0.9211 mL | 1.8422 mL | 3.6843 mL |
| 20mM | 0.0921 mL | 0.4605 mL | 0.9211 mL | 1.8422 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.