Nidufexor, formerly known as LMB 763, is a novel, potent and orally bioactive farnesoid X receptor (FXR) agonist.

Lithocholic acid (3α-Hydroxy-5β-cholanic acid), a secondary bile acid formed from chenodeoxycholate by bacterial action, acts as a detergent to solubilize fats for absorption and is itself absorbed.

Guggulsterone (Guglip; Pregna-4,17(20)-diene-3,16-dione) is a potent and broad spectrum antagonist of steroid receptor ligand FXR with various biological activities.

Fexaramine is a novel, potent, selective small molecule agonist of farnesoid X receptor (FXR) agonist with an EC50 of 25 nM and with 100-fold increased affinity relative to natural compounds.

Tropifexor (also known as LJN452) is a novel, potent and highly potent agonist of FXR (farnesoid X receptor) with an EC50 value of 0.2 nM in HTRF assay.

Ursodiol (UDCA; Ursodeoxycholic acid) is a novel and natural bile acid with significant colon chemopreventive activity.

Turofexorate Isopropyl (also known as WAY-362450, Fxr 450 and XL335) is a novel, highly potent, selective and orally bioavailable FXR (farnesoid X receptor) agonist with EC50 of 4 nM, it is highly selective versus other nuclear receptors, such as LXR, PPAR, ER and etc.

Chenodeoxycholic acid (Anthropodesoxycholic acid; Anthropodeoxycholic acid) is a naturally occurring bile acid (found in the body) acting as an apoptosis inducer via PKC-dependent signalling pathway.

BAR502 is a dual FXR and GPBAR1 agonist.

LY2562175 (LY-2562175) is a novel, potent and selective FXR agonist (EC50 = 193 nM) with lipid modulating activity, e.g. lowering LDL and triglycerides while raising HDL in preclinical species.