GSK8612
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1250 | In Stock |
| 500mg | $1950 | In Stock |
| 1g | $2925 | In Stock |
: Cat #: V4435 CAS #: 2361659-62-1 Purity ≥ 98%
Description: GSK8612 is a novel, potent and highly selective small molecule inhibitor of Tank-binding Kinase-1 (TBK1) with a pIC50 of 6.8 for recombinant TBK1.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 520.33 |
|---|---|
| Molecular Formula | C17H17BrF3N7O2S |
| CAS No. | 2361659-62-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=S(C1=CC=C(CNC2=NC(NC3=CN(CC(F)(F)F)N=C3C)=NC=C2Br)C=C1)(N)=O |
| Synonyms | GSK8612; GSK-8612; GSK 8612; |
| Protocol | In Vitro | GSK8612 inhibits toll-like receptor (TLR)3-induced IRF3 phosphorylation in Ramos cells and type I IFN secretion in primary human mononuclear cells. In THP1 cells, GSK8612 is able to inhibit secretion of IFNβ in response to dsDNA and cGAMP, the natural ligand for STING. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9219 mL | 9.6093 mL | 19.2186 mL | 38.4371 mL |
| 5mM | 0.3844 mL | 1.9219 mL | 3.8437 mL | 7.6874 mL |
| 10mM | 0.1922 mL | 0.9609 mL | 1.9219 mL | 3.8437 mL |
| 20mM | 0.0961 mL | 0.4805 mL | 0.9609 mL | 1.9219 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.