GSK3145095
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $2200 | Check With Us |
| 200mg | $3300 | Check With Us |
| 500mg | $5565 | Check With Us |
: Cat #: V32475 CAS #: 1622849-43-7 Purity ≥ 98%
Description: GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM .
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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| Molecular Weight (MW) | 397.38 |
|---|---|
| Molecular Formula | C20H17F2N5O2 |
| CAS No. | 1622849-43-7 |
| SMILES Code | O=C(C1=NN=C(CC2=CC=CC=C2)N1)N[C@H]3CCC4=CC(F)=CC(F)=C4NC3=O |
| Synonyms | GSK-3145095; GSK 3145095; GSK3145095 |
| Protocol | In Vitro | GSK3145095 potently blocks the TNF response as shown by determination of overall cell viability as measured by cellular ATP levels (IC50 = 1.6 nM), cell death as measured by LDH release (IC50 = 0.5 nM) and RIP1-dependent inflammatory cytokine MIP-1β production, either as absolute levels for protein, or fold changes in mRNA expression (IC50 = 0.4 nM) . |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5165 mL | 12.5824 mL | 25.1648 mL | 50.3297 mL |
| 5mM | 0.5033 mL | 2.5165 mL | 5.0330 mL | 10.0659 mL |
| 10mM | 0.2516 mL | 1.2582 mL | 2.5165 mL | 5.0330 mL |
| 20mM | 0.1258 mL | 0.6291 mL | 1.2582 mL | 2.5165 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.