GSK2983559 free acid

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$1650	Check With Us
500mg	$2750	Check With Us
1g	$4125	Check With Us

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Cat #: V34660 CAS #: 1579965-12-0 Purity ≥ 99%

Description: GSK2983559 free acid (compound 3) is a potent, specific and oral bioactive receptor interacting protein 2 (RIP2) kinase inhibitor, showing excellent activity in blocking many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples.

References: Tso SC, et al. Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase. J Biol Chem. 2014 Jul 25;289(30):20583-93.

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Physicochemical and Storage Information
Protocol
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Stock Solution Preparation
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Molecular Weight (MW)	247.10
Molecular Formula	C9H4Cl2O2S
CAS No.	1579965-12-0
SMILES Code	O=C(C1=C(Cl)C2=CC=C(Cl)C=C2S1)O
Synonyms	BT2; BT-2; BT 2;

Protocol	In Vivo	BT2 (20 mg/kg/day; intraperitoneal injection; daily; for 7 days; C57BL/6J male mice) treatment robustly enhances BCKDC activity in the heart (12.3-fold) compared with the vehicle-treated animals. Less activation is obtained in muscle and kidney at 3.6- and 3.8-fold, respectively. The -fold activation of BCKDC activity in the above tissues correlates with decreased phosphorylation in heart, muscle, and kidney after the long term BT2 treatment. BT2 treatment reduces the protein levels of BDK in kidneys and heart.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	4.0469 mL	20.2347 mL	40.4694 mL	80.9389 mL
5mM	0.8094 mL	4.0469 mL	8.0939 mL	16.1878 mL
10mM	0.4047 mL	2.0235 mL	4.0469 mL	8.0939 mL
20mM	0.2023 mL	1.0117 mL	2.0235 mL	4.0469 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.