GSK2643943A
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1290 | Check With Us |
| 500mg | $1850 | Check With Us |
| 1g | $2775 | Check With Us |
: Cat #: V3964 CAS #: N/A Purity ≥ 98%
Description: GSK2643943A is a novel and potent inhibitor of deubiquitylating enzyme (DUB) with an IC50 of 160 nM for USP20/Ub-Rho.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 277.30 |
|---|---|
| Molecular Formula | C17H12FN3 |
| CAS No. | N/A |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: >10 mMr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | N#CC1=C(N)NC2=C1C=CC(/C=C/C3=CC=CC(F)=C3)=C2 |
| Synonyms | GSK2643943; GSK 2643943; GSK-2643943; GSK2643943A; GSK 2643943A; GSK-2643943A; |
| Protocol | In Vitro | GSK2643943A blocks the USP20-mediated cleavage of protein-ubiquitin bonds |
|---|---|---|
| In Vivo | GSK2643943A (5 mg/kg, i.p., daily, for 6 days) potentiates oHSV-1-induced oncolysis in SCC9 tumors | |
| Animal model | The subcutaneous xenograft model | |
| Dosages | 5 mg/kg | |
| Administration | intraperitoneal administration, daily, for 6 days. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.6062 mL | 18.0310 mL | 36.0620 mL | 72.1241 mL |
| 5mM | 0.7212 mL | 3.6062 mL | 7.2124 mL | 14.4248 mL |
| 10mM | 0.3606 mL | 1.8031 mL | 3.6062 mL | 7.2124 mL |
| 20mM | 0.1803 mL | 0.9016 mL | 1.8031 mL | 3.6062 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.