PR-619 (PR619; PR 619) is a novel, cell-permeable, non-selective and reversible inhibitor of the deubiquitinylating enzymes (DUBs) with potential antineoplastic activity.

IU1-47 is a potent and selective inhibitor of USP14.

P22077 (P-22077; P 22077) is a potent, cell-permeable and selective inhibitor of ubiquitin-specific protease USP7 (ubiquitin-specific protease 7) with potential antitumor activity.

AZ1 is a novel and potent dual inhibitor of the USP25/28 deubiquitinating enzyme subfamily with potential anticancer activity.

RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS).

PLpro inhibitor is a novel and potent inhibitor of papain-like protease (PLpro) with IC50 of 2.6 uM.

ML323 (ML-323; ML 323) is a novel, potent and highly selective USP1-UAF1 inhibitor with potential antitumor activity.

ML364 is a small molecule inhibitor of ubiquitin specific peptidase 2 (USP2, a deubiquitinase) with an IC50 of 1.1 μm in a biochemical assay.

GSK2643943A is a novel and potent inhibitor of deubiquitylating enzyme (DUB) with an IC50 of 160 nM for USP20/Ub-Rho.

NSC632839 is a nonselective isopeptidase inhibitor that inhibits USP2, USP7, and SENP2 with EC50 values of 45±4 μM, 37±1 μM, and 9.8±1.8 μM, respectively.