GSK137647A
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $469 | Check With Us |
| 500mg | $780 | Check With Us |
| 1g | $1170 | Check With Us |
: Cat #: V2812 CAS #: 349085-82-1 Purity ≥ 98%
Description: GSK137647A, a diarylsulfonamide analog, is a novel, potent and selective agonists of the free fatty acid receptor 4 (FFA4/GPR120) with pEC50 of 6.3, 6.2, and 6.1 for human, mouse and rat FFA4, respectively.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 305.39 |
|---|---|
| Molecular Formula | C₁₆H₁₉NO₃S |
| CAS No. | 349085-82-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 30 mg/mLr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | O=S(C1=CC=C(OC)C=C1)(NC2=C(C)C=C(C)C=C2C)=O |
| Synonyms | GSK137647; GSK-137647; GSK 137647; GSK137647A; GSK-137647A; GSK 137647A |
| Protocol | In Vitro | GSK137647A (GSK 137647) (50 µM) reduces the production of NO in macrophages without affecting cell viability |
|---|---|---|
| In Vivo | GSK137647A (GSK 137647) (1 mg/kg; i.p.; twice daily, for 7 days; C57BL/6 mice) alleviates colitis in TNBS- and DSS-treated mice | |
| Animal model | Male C57BL/6 mice | |
| Dosages | 1 mg/kg | |
| Administration | Intraperitoneal injection; twice daily, for 7 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.2745 mL | 16.3725 mL | 32.7450 mL | 65.4900 mL |
| 5mM | 0.6549 mL | 3.2745 mL | 6.5490 mL | 13.0980 mL |
| 10mM | 0.3275 mL | 1.6373 mL | 3.2745 mL | 6.5490 mL |
| 20mM | 0.1637 mL | 0.8186 mL | 1.6373 mL | 3.2745 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.