GNE-6776

This product is for research use only, not for human use. We do not sell to patients.

GNE-6776
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1650Check With Us
250mg$2650Check With Us
500mg$3975Check With Us

Cat #: V3028 CAS #: 2009273-71-4 Purity ≥ 98%

Description: GNE-6776 (GNE6776) is a novel, highly potent, specific, non-covalent, and orally bioavailable USP7 (Ubiquitin specific proteases7) inhibitor with anticancer activity.

References: Lorna Kategaya , et al. USP7 Small-Molecule Inhibitors Interfere With Ubiquitin Binding. Nature. 2017 Oct 26;550(7677):534-538.

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Molecular Weight (MW)348.406
Molecular FormulaC20H20N4O2
CAS No.2009273-71-4
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: ≥ 310 mg/mLr
Water: <1 mg/mLr
Ethanol: 1 mg/mL
SynonymsGNE-6776; GNE6776; GNE 6776
ProtocolIn VitroGNE-6776 significantly inhibits USP7 at 15 µM. GNE-6776 is a highly selective USP7 inhibitor against both recombinant and endogenous cellular deubiquitinases
In VivoGNE-6776 (100 or 200 mg/kg; oral gavage on a once or twice daily schedule; for 10 days) inhibits EOL-1 xenograft growth in mice
Animal modelImmunodeficient C.B-17 SCID mice (aged 12-16 weeks) with EOL1 AML xenograft
Dosages100 or 200 mg/kg
AdministrationOral gavage on a once or twice daily schedule; for 10 days
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.8702 mL14.3511 mL28.7021 mL57.4043 mL
5mM0.5740 mL2.8702 mL5.7404 mL11.4809 mL
10mM0.2870 mL1.4351 mL2.8702 mL5.7404 mL
20mM0.1435 mL0.7176 mL1.4351 mL2.8702 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.