GNE-6776
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
Size | Price | Stock |
---|---|---|
100mg | $1650 | Check With Us |
250mg | $2650 | Check With Us |
500mg | $3975 | Check With Us |
Cat #: V3028 CAS #: 2009273-71-4 Purity ≥ 98%
Description: GNE-6776 (GNE6776) is a novel, highly potent, specific, non-covalent, and orally bioavailable USP7 (Ubiquitin specific proteases7) inhibitor with anticancer activity.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
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Molecular Weight (MW) | 348.406 |
---|---|
Molecular Formula | C20H20N4O2 |
CAS No. | 2009273-71-4 |
Storage | -20℃ for 3 years in powder formr |
-80℃ for 2 years in solvent | |
Solubility In Vitro | DMSO: ≥ 310 mg/mLr |
Water: <1 mg/mLr | |
Ethanol: 1 mg/mL | |
Synonyms | GNE-6776; GNE6776; GNE 6776 |
Protocol | In Vitro | GNE-6776 significantly inhibits USP7 at 15 µM. GNE-6776 is a highly selective USP7 inhibitor against both recombinant and endogenous cellular deubiquitinases |
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In Vivo | GNE-6776 (100 or 200 mg/kg; oral gavage on a once or twice daily schedule; for 10 days) inhibits EOL-1 xenograft growth in mice | |
Animal model | Immunodeficient C.B-17 SCID mice (aged 12-16 weeks) with EOL1 AML xenograft | |
Dosages | 100 or 200 mg/kg | |
Administration | Oral gavage on a once or twice daily schedule; for 10 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
Solvent volume to be added | Mass (the weight of a compound) | |||
---|---|---|---|---|
Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
1mM | 2.8702 mL | 14.3511 mL | 28.7021 mL | 57.4043 mL |
5mM | 0.5740 mL | 2.8702 mL | 5.7404 mL | 11.4809 mL |
10mM | 0.2870 mL | 1.4351 mL | 2.8702 mL | 5.7404 mL |
20mM | 0.1435 mL | 0.7176 mL | 1.4351 mL | 2.8702 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.