Glyburide (Glibenclamide)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
50g	$450	Check With Us
100g	$700	Check With Us
200mg	$1050	Check With Us

: [email protected] [email protected]

Cat #: V1678 CAS #: 10238-21-8 Purity ≥ 98%

Description: Glyburide (formerly HB419; HB420; Glibenclamide; Micronase; Diabeta; Maninil; Micronase; Neogluconin) is a selective blocker of vascular ATP-sensitive K+ channels (KATP) that has been approved as an antidiabetic sulfonylurea drug used for the treatment of type 2 diabetes.

References: Qiu Y, et al. Glyburide Regulates UCP1 Expression in Adipocytes Independent of KATP Channel Blockade. iScience. 2020;23(9):101446.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	494
Molecular Formula	C23H28ClN3O5S
CAS No.	10238-21-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 99 mg/mL (200.4 mM)r
	Water:<1 mg/mLr
	Ethanol:<1 mg/mL
Synonyms	HB-420; Glyburide; Glibenclamide; HB419; HB420; Micronase; Diabeta; Maninil; Micronase; Neogluconin

Protocol	In Vitro	Glibenclamide (brown adipocytes; 10 μM； 1 day) has no effect on adipocyte differentiation. Glibenclamide (Ucp1-2A-GFP brown adipocyte) significantly increased UCP1 expression. Glibenclamide directly binds to and blocks ATP-dependent potassium channels (KATP), which increases insulin secretion by pancreatic β cells
Protocol	In Vivo	Glibenclamide (2 mg/kg； po) Increases insulin release and rapidly lowers blood sugar levels

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.0243 mL	10.1215 mL	20.2429 mL	40.4858 mL
5mM	0.4049 mL	2.0243 mL	4.0486 mL	8.0972 mL
10mM	0.2024 mL	1.0121 mL	2.0243 mL	4.0486 mL
20mM	0.1012 mL	0.5061 mL	1.0121 mL	2.0243 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.