G10
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1550 | Check With Us |
| 500mg | $2350 | Check With Us |
| 1g | $3525 | Check With Us |
: Cat #: V21450 CAS #: 702662-50-8 Purity ≥ 98%
Description: G10 (STING agonist-1) is a novel, potent human-specific STING agonist, triggering IRF3/IFN-associated transcription in human fibroblasts.
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| Molecular Weight (MW) | 430.88 |
|---|---|
| Molecular Formula | C21H16ClFN2O3S |
| CAS No. | 702662-50-8 |
| SMILES Code | O=C(C1=CC=C(C(N2CC3=C(F)C=CC=C3Cl)=C1)SCC2=O)NCC4=CC=CO4 |
| Synonyms | G10; G-10; G 10; STING agonist G10; |
| Protocol | In Vitro | G10 induces innate antiviral mRNA expression in primary human cells. G10 induces STING-dependent synthesis and secretion of bioactive interferon. STING is required for G10-mediated IRF3 activation, gene expression, and anti-Alphaviral activity. G10-mediated IRF3 activation and anti-Alphaviral activity occur independently of IPS-1/MAVS-dependent signaling. G10 is an indirect activator of human STING-dependent phenotypes. G10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3208 mL | 11.6042 mL | 23.2083 mL | 46.4166 mL |
| 5mM | 0.4642 mL | 2.3208 mL | 4.6417 mL | 9.2833 mL |
| 10mM | 0.2321 mL | 1.1604 mL | 2.3208 mL | 4.6417 mL |
| 20mM | 0.1160 mL | 0.5802 mL | 1.1604 mL | 2.3208 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.