Fulvestrant (ICI 182780)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $330 | In Stock |
| 1g | $550 | In Stock |
| 5g | $1485 | In Stock |
: Cat #: V1721 CAS #: 129453-61-8 Purity ≥ 98%
Description: Fulvestrant (ICI-182780; ZD-9238; ZM-182780; Faslodex) is a synthetic and potent estrogen receptor (ER) antagonist approved as a medication for the treatment of hormone receptor (HR)-positive breast cancer in postmenopausal women.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 606.77 |
|---|---|
| Molecular Formula | C32H47F5O3S |
| CAS No. | 129453-61-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (164.8 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 100 mg/mL (164.8 mM) | |
| Solubility In Vivo | 5% DMSO+95% Corn oil: 30mg/mL |
| Synonyms | ZD9238; ICI-182780; ZM182780; ZD-9238; ICI182780; ZM 182780; ZD 9238; ICI 182780; ZM-182780; Fulvestrant; Faslodex. |
| Protocol | In Vitro | FuLvestrant (ICI 182780; ZD 9238; ZM 182780) is a potent and specific inhibitor of estrogenic action that exhibits excellent growth inhibition in both human breast cancer cells and animal models. FuLvestrant inhibits the growth of MCF-7 human breast cancer cells, IC50 is 0.29 nM. Fulvestrant has a relative binding affinity of 0.89. FuLvestrant has significantly enhanced anti-estrogen potency and preserves pure estrogen antagonist activity |
|---|---|---|
| In Vivo | When Fulvestrant (ICI 182,780) is administered alone, parenteral (s.c.) has no uterotropic activity in immature female rats. Fulvestrant (0.5 mg/kg/day s.c) showed complete antagonism to estrogenic action. Fulvestrant oral administration (5 mg/kg/day) is similar in nature to subcutaneous administration |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.6481 mL | 8.2404 mL | 16.4807 mL | 32.9614 mL |
| 5mM | 0.3296 mL | 1.6481 mL | 3.2961 mL | 6.5923 mL |
| 10mM | 0.1648 mL | 0.8240 mL | 1.6481 mL | 3.2961 mL |
| 20mM | 0.0824 mL | 0.4120 mL | 0.8240 mL | 1.6481 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.