FTI-2148 | CAS 251577-09-0

FTI-2148

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$1250	Check With Us
200mg	$1875	Check With Us
500mg	$3165	Check With Us

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Cat #: V21386 CAS #: 251577-09-0 Purity ≥ 98%

Description: FTI-2148, a RAS C-terminal mimetic, is a novel, potent and highly selective dual inhibitor of farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) with IC50s of 1.4 nM and 1.7 μM, respectively.

References: Sun J, et al. Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.Cancer Res. 1999 Oc

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Quality Control Documentation

Molecular Weight (MW)	452.57
Molecular Formula	C24H28N4O3S
CAS No.	251577-09-0
SMILES Code	CSCC[C@H](NC(C1=CC=C(C=C1C2=CC=CC=C2C)CNCC3=CNC=N3)=O)C(O)=O

Protocol	In Vitro	FTI-2148 (30 μM) inhibits the farnesylation of the exclusively farnesylated protein HDJ2 in all 3 RAS-transformed NIH3T3 cells.
Protocol	In Vivo	FTI-2148 (subcutaneous injection; 100 mg/kg/day; 14 days) results in breast tumor regression in a ras transgenic mouse model. FTI-2148 (subcutaneous injection; 25 mpk/day with a mini-pump; 14 days) inhibits tumor growth by 77%by the end of the 2-week treatment in Human Xenograft Nude Mouse Model. FTI-2148 (intraperitoneal injection; 25 or 50 mpk/day with a mini-pump; started on day 15 and stopped on day 45 and restarted day 53-83) inhibits the tumor growth by 91% in human lung adenocarcinoma A-549 cells induced mouse model.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2096 mL	11.0480 mL	22.0960 mL	44.1921 mL
5mM	0.4419 mL	2.2096 mL	4.4192 mL	8.8384 mL
10mM	0.2210 mL	1.1048 mL	2.2096 mL	4.4192 mL
20mM	0.1105 mL	0.5524 mL	1.1048 mL	2.2096 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.